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11월 7일(금) 특별초청 세미나 안내, 연사: Prof. Jeffrey R. Long, Prof. Christopher J. Chang |
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일시 : 2008년 11월 7일 오후 4시
장소 : 종합과학관 B동 153호
연사 : Prof. Jeffrey R. Long (Dept. of Chemistry, University of Califnia, Berkeley)
연제 : Hydrogen Stage in Micropous Metal-ganic Framewks with Exposed Metal Sites
내용 : Materials exhibiting reversible hydrogen adsption with high gravimetric volumetric capacities are sought f use in on-board stage systems of hydrogen fuel cell-powered vehicles. Micropous metal-ganic framewks with high internal surface areas have been shown to display excellent stage properties, but only at cryogenic temperatures. Methods f synthesizing framewks containing codinatively-unsaturated metal centers are therefe being developed as a means of increasing the H2 adsption enthalpy. In particular, we seek to synthesize thermally-robust, high-surface area materials with a high concentration of open metal codination sites. By adjusting the electronic structure of the metal ions, it is expected that an optimal H2 binding enthalpy of 14 kJ/mol can be achieved, leading to a high H2 stage capacity at room temperature safe pressures of up to 100 bar. Our approaches involve the ion activation of metal carbonyl units on the aromatic components of existing framewks, as well as the design of new framewks using bridging ligs that facilitate the generation of open metal codination sites.
일시 : 2008년 11월 7일 오후 5시
장소 : 종합과학관 B동 153호
연사 : Prof. Christopher J. Chang (Dept. of Chemistry, University of Califnia, Berkeley)
연제 : CHEMICAL APPROACHES TO UNDERSTING METAL OXIDATION BIOLOGY IN THE BRAIN
내용 : The brain requires among the highest concentrations of copper iron in the body f nmal physiology, but cellular mismanagement of these redox-active metals their contribution to oxidative stress is connected to Alzheimer’s, Parkinson’s, related neurodegenerative diseases. Motivated to interrogate the complex roles of metal ions redox biology in neurological health disease, we are developing new small-molecule fluescent probes to ively track metal ions oxygen metabolites in living cells at the molecular level. The synthesis characterization of our most recent fluophe platfms their application f molecular imaging in living systems will be presented.
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